In Vivo Cellular Reprogramming: The Next Generation

In Vivo Cellular Reprogramming: The Next Generation

Cellular reprogramming technology has created new opportunities in understanding human disease, drug discovery, and regenerative medicine. While a combinatorial code was initially found to reprogram somatic cells to pluripotency, a "second generation" of cellular reprogramming involves lineage-restricted transcription factors and microRNAs that directly reprogram one somatic cell to another. Th...

Neuroregeneration using in vivo cellular reprogramming

Epigenetic reprogramming: preparing the epigenome for the next generation.

Epigenetic reprogramming of germ cells involves the genome-wide erasure and subsequent re-establishment of DNA methylation, along with reprogramming of histone modification profiles and the eventual incorporation of histone variants. These linked processes appear to be key for the establishment of the correct epigenetic regulation of this cell lineage. Mouse studies indicate that DNA demethylat...

I-10: Transcriptomics in Oocyte Mediated Cellular Reprogramming

a:4:{s:10:"Background";s:1707:"Early embryonic development in mammals begins in transcriptional silence with an oocyte-mediated transcriptional reprogramming of parental gametes occurs during a so called across-the-board process of “erase-and-rebuild”. In this process, the parental transcription programs are erased long before (maternal) or soon thereafter (paternal) fertilization to generate a...

Ex vivo expansion of hematopoietic precursors, progenitors, and stem cells: the next generation of cellular therapeutics.

INCE ITS INCEPTION as a medical specialty, hematolS ogy has had the unique perspective of considering therapeutics to include not only small molecular weight pharmaceuticals, but also cells themselves. Recognizing the complexity of the functions performed by the blood cells, hematologists have long understood that our best chance of harnessing the power of these cells for oxygen transport, repa...